Antidiabetic effect of aqueous stem bark extract of Parinari macrophylla in alloxan-induced diabetic Wistar rats

Abstract Background Diabetes is a major public health problem with increasing prevalence globally. Plant-based medicines for diabetes are gaining popularity across the world due to perceptions of efficacy, safety and cost-effectiveness. The plant, Parinari macrophylla , has been widely reported possess potent ethnomedicinal properties especially in northern part Nigeria. However, there no scientific documentation this plant be used as an antidiabetic agent. objective study was investigate effect aqueous stem bark extract P. alloxan-induced diabetic Wistar rats. Phytochemical screening acute toxicity studies were conducted. rats weighing between 100 150 g induced using alloxan monohydrate (150 mg/kg) intraperitoneally. animals treated different doses (1000 mg/kg 2000 2 weeks. Blood glucose levels body weight then monitored. Histopathological investigation pancreatic tissue also Results phytochemical analysis revealed presence alkaloids, saponins, tannins, cardiac glycosides, carbohydrates, steroids, triterpenes secondary metabolites. test mortality median lethal dose determined above 5000 mg/kg. Although two decreased blood at weeks 1 2, statistically significant difference ( P < 0.05) only observed group compared control week 2. histological that caused regeneration islet cells, being more evident. Conclusion This suggests possesses may potentially treat associated complications. Graphical